2.SPIRONOLACTONE (ALDECTONE) - SA Anabolics

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2.SPIRONOLACTONE (ALDECTONE)

PRODUCT INFO > 06. DIURETICS


DRUG CLASS: POTASSIUM SPARING DIURETIC (ORAL)
ACTIVE-LIFE: 10-12 HOURS
AVERAGE REPORTED DOSAGE: 50-200MG (TOTAL) DAILY
ACNE: NONE
WATER RETENTION: YOU MUST BE JOKING!
HIGH BLOOD PRESSURE: NONE
LIVER TOXIC: UNKNOWN
AROMATIZATION: DOES NOT APPLY

SPIRONOTHIAZID IS A DIURETEIC AND AN ALDOSTERONE ANTAGONIST. THIS MEANS THAT IT SUPPRESSES THE WATER RETAINING ACTIONS OF THE HORMONE ALDOSTERONE WHILE LOWERING WATER RETENTION BY LOWERING ELECTROLYTES (POTASSIUM, SODIUM, AND CALCIUM). THE ADVANTAGE OF THE COMBINATION IS THAT THE POTASSIUM ABSORPTION EFFECT BY THE SPIRONOLACTONE CAN BE MEDIATED BY THE HYDROCHLORTHIAZIDE. BECAUSE OF THIS, SOME OF THE POTASSIUM LOSS SIDE EFFECTS CAN BE AVOIDED. THIS IS PROBABLY A SAFER CHOICE THAN LASIX THOUGH ANY DIURETIC USE SHOULD BE MEDICALLY MONITORED. THIAZIDES ALSO LEAD TO A LOWER LOSS OF CALCIUM.
SIDE EFFECTS ARE COMMONLY DUE TO IMBALANCES IN ELECTROLYTES AND FLUIDS. THEY CAN INCLUDE IRREGULAR PULSE RATE, CRAMPS, AND LIGHT HEADINESS. SINCE THE DRUG HAS ANTI-ANDROGENIC QUALITY (SPIRONOLACTONE), MEN CAN EXPERIENCE POSSIBLE GYNO, AND IMPOTENCE DUE TO HIGHER DOSAGE AND/OR PROLONGED USE. THESE WERE NOTED TO NOT OCCUR DUE TO THE BRIEF ADMINISTRATION PERIOD NORMALLY EMPLOYED. ACCORDING TO AVAILABLE LITERATURE, IT IS BEST TO AVOID HIGHER POTASSIUM INTAKE DURING USE. DOSAGES WERE USUALLY 50-150MG A DAY FOR NO MORE THAN 3 DAYS. DOSAGES WERE DIVIDED INTO 2-3 DAILY DOSAGES.
POTASSIUM SPARING DIURETICS

POTASSIUM SPARING DIURETIC DRUGS ARE OFTEN SAID TO BE THE SAFEST. THOUGH I DO NOT NECESSARILY AGREE. DRUGS SUCH AS ALDACTONE AND ALDACTAZIDE ARE EXAMPLES OF THIS GROUP AND THEY ACT AS ALDOSTERONE ANTAGONIST. ALDOSTERONE IS THE HORMONE THE BODY USES TO REGULATE WATER RETENTION ENDOGENOUSLY. IN SHORT, FOR NOW, ALDOSTERONE ELEVATION EQUALS WATER RETENTION/ELEVATION. SINCE POTASSIUM-SPARING DIURETICS WORK BY INHIBITING THE ACTIVITY OF ALDOSTERONE, THE RESULT IS GREATER SODIUM AND WATER EXCRETION, AND INCREASED POTASSIUM RETENTION. PROBLEMS ARISE WHEN ATHLETES INGEST ADDITIONAL POTASSIUM WITHOUT THE GUIDANCE OF A DOCTOR DARING USE OF THESE DRUGS. SOME USERS ASSUME MUSCLE CRAMPS ARE DUE TO IMBALANCES OF OTHER ELECTROLYTES IN ALL BUT THE RAREST CASES. SUPPLEMENTATION WITH OVER THE COUNTER POTASSIUM PRODUCTS DURING USE CAN RESULT IN HEART ATTACK. PERSONALLY I DISLIKED THE ANTI-ANDROGEN EFFECT OF THESE DRUGS. SOME ATHLETES EXPERIENCE GYNO DURING USE AND ASSUME IT IS DUE TO ESTROGENIC ACTIVITY. THEY OFTEN INCREASE DIURETIC DOSAGES ASSUMING "WITH ESTROGEN COMES WATER". SINCE POTASSIUM SPARING DIURETICS REQUIRE 7-14 DAYS TO PROVIDE MAXIMUM RESULTS, DOSAGES CAN AGAIN BE EASILY MISJUDGED. I BELIEVE THEY ARE NOT ALL THAT SAFE.
PRODUCTS AVAILIBLE IN SOUTH AFRICA

1.PFIZER  SOUTH AFRICA=ALDECTONE(25MG-100MG SPIRONOLACTONE/TAB=30 TABS) VERY GOOD
QUALITY PRODUCT.EXCPECT TO PAY R15 PER TAB
2.PFIZER  SOUTH AFRICA=ALDAZIDE(25MG SPIRONOLACTONE+2.5MG ISOBUTYLHYDROCLOROTTHIAZIDE/TAB=30 TABS) VERY GOOD QUALITY PRODUCT.EXCPECT TO PAY R15 PER TAB


1.pfizer sa=aldectone
 
2.pfizer sa=aldazide
 
 
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